Outcomes of artificial urinary sphincter placement in octogenarians

OBJECTIVE - To evaluate the impact of patient age on device outcomes among patients undergoing primary artificial urinary sphincter.

METHODS - A total of 1081 male patients who underwent primary artificial urinary sphincter placement from 1983 to 2011 were analyzed, including 91 men (8%) who were aged >80 years at the time of surgery.

Revisions and explanations were compared between men stratified by decade of life. Hazard ratios adjusting for competing risks were used to determine the association with age and artificial urinary sphincter device outcomes (infection/erosion, urethral atrophy and malfunction), while overall device failure was estimated using Kaplan-Meier and Cox regression analysis.

RESULTS - Patients aged >80 years were more likely to have coronary disease (P = 0. 009), diabetes mellitus (P = 0. 04), hypertension (P = 0. 002) and lower body mass index (P < 0. 0001). On multivariable analysis, patients aged >80 years were significantly more likely to experience device erosion or infection compared with a reference of patients aged <60 years (hazard ratio 4. 13; P = 0. 046), whereas there was no difference in those patients aged 60-70 years or 70-80 years compared with the reference group (P = 0. 56 and 0. 45). There was no significant difference in overall device survival between the age-stratified groups (P = 0. 26).

CONCLUSIONS - Although overall artificial urinary sphincter device survival is similar, patients aged >80 years are more likely to experience erosion or infection compared with younger patients. Despite this, the overall device failure rate is low, and artificial urinary sphincter might be considered for appropriately selected and counseled octogenarians.

International journal of urology : official journal of the Japanese Urological Association. 2016 Feb 18 [Epub ahead of print]

Matthew J Ziegelmann, Brian J Linder, Marcelino E Rivera, Boyd R Viers, Laureano J Rangel, Daniel S Elliott

Section of Pelvic and Reconstructive Surgery, Department of Urology, Mayo Clinic, Rochester, Minnesota, USA. , Section of Pelvic and Reconstructive Surgery, Department of Urology, Mayo Clinic, Rochester, Minnesota, USA. , Section of Pelvic and Reconstructive Surgery, Department of Urology, Mayo Clinic, Rochester, Minnesota, USA. , Section of Pelvic and Reconstructive Surgery, Department of Urology, Mayo Clinic, Rochester, Minnesota, USA. , Section of Pelvic and Reconstructive Surgery, Department of Urology, Mayo Clinic, Rochester, Minnesota, USA. , Section of Pelvic and Reconstructive Surgery, Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.

PubMed

Pelvic Health Weekly Newsletter