Association between Stress Urinary Incontinence and the Components of Metabolic Syndrome among Females 20-59 years.

To assess the relationship between stress urinary incontinence (SUI) and metabolic syndrome among a population-based cohort of women 20-59 years.

NHANES database was used between the years of 2013- 2016 and included women aged 20-59 years.

SUI was defined as "Urinary leakage with physical activity". Metabolic syndrome was defined as > 2 risk factors: fasting blood glucose > 99 mg/dl, triglyceride > 149 mg/dl, high-density lipoprotein < 50 mg/dl, waistline > 88cm, and blood pressure > 130/85. We generated weighted estimated prevalence and ran multivariable logistic regression models.

Among 3,430 female subjects, the estimated prevalence of SUI was 38.7% (95% CI 36.7-40.7%) and metabolic syndrome was 10.2% (95% CI 8.9-11.6). Higher rates of SUI were seen with large waistlines, elevated fasting blood glucose (FBG), and elevated triglycerides. Among women with metabolic syndrome, 56.1% (95% CI 39.7-49.0%) had SUI. Among all women, metabolic syndrome and elevated FBG significantly increase the risk of SUI (OR 1.53 (95% CI 1.02-2.28 and OR 1.86 (95% CI 1.14-3.03) respectively). In women 20-39 years, a large waistline significantly increased the risk of SUI (OR 1.72 (95% CI 1.00- 2.99).

Among females 20-59 years in the United States, 38.7% report SUI and 10% have metabolic syndrome. Metabolic syndrome and an elevated FBG significantly increase the risk of SUI among all women. A large waistline increases the risk of SUI in women aged 20-39 years. Weight loss and adequate control of metabolic syndrome should be considered key strategies in the management of SUI.

Urology. 2020 Jul 28 [Epub ahead of print]

Stephanie Gleicher, Timothy Byler, Natasha Ginzburg

Department of Urology, SUNY Upstate Medical University, Syracuse New York 13210., Department of Urology, SUNY Upstate Medical University, Syracuse New York 13210. Electronic address: .

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