Cell-based therapy for the treatment of female stress urinary incontinence: an early cost-effectiveness analysis

To perform an early cost-effectiveness analysis of in vitro expanded myoblasts (IVM) and minced myofibers versus midurethral slings (MUS) for surgical treatment of female stress urinary incontinence.

Cost-effectiveness and sensitivity analyses were performed using a decision tree comprising previously published data and expert opinions.

In the base case scenario, MUS was the cost-effective strategy with a negative incremental cost-effectiveness ratio compared with IVM and a positive incremental cost-effectiveness ratio compared with minced myofibers. However, the sensitivity analysis indicates that IVM may become an alternative providing greater effect at a higher cost. With the possibility of becoming more effective, IVM treatment would be advantageous over MUS given its reduced invasiveness and lower risks of complications.

Regenerative medicine. 2018 May 01 [Epub]

Andreas West Vilsbøll, Jakob Munk Mouritsen, Line Park Jensen, Nikolaj Bødker, Annette Willemoes Holst, Cristian P Pennisi, Lars Ehlers

Department of Health Science & Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark., Danish Center for Healthcare Improvements, Aalborg University, Aalborg, Denmark.