von Brunn's Nests and Follicular Cystitis Following Intradetrusor OnabotulinumtoxinA Injections for Overactive Bladder

A 67-year-old female with refractory OAB was treated with intradetrusor Botox. She subsequently developed multiple papillary bladder lesions with tissue biopsy showing Von Brunn's nests. Von Brunn's nests are benign bladder lesions similar in appearance to a rare urothelial tumor called Nested Variant of Urothelial Carcinoma (NVUC). It is critical that patients with these findings undergo evaluation to rule out the presence of carcinoma. This finding suggests the possibility of a previously unreported adverse reaction in association with intradetrusor Botox.

Urology case reports. 2017 Aug 08*** epublish ***

Silpa Nekkanti, Andrew Doering, Debra L Zynger, Andrew F Hundley

The Ohio State University Wexner Medical Center, Dept. of Obstetrics and Gynecology, 395 W. 12th Ave., Suite 522, Columbus, OH, 43210, USA., The Ohio State University Wexner Medical Center, Dept. of Pathology, 410 W. 10th Ave., E401 Doan Hall, Columbus, OH, 43210, USA.