The efficacy of different doses of solifenacin in elderly patients after treating a urinary tract infection

To determine the efficacy and safety of solifenacin for correcting the residual symptoms of an overactive bladder (OAB) in patients who were treated for a urinary tract infection (UTI).

Using random sampling, 524 patients aged >60 years were selected (347 women, 66. 2%, and 177 men, 33. 8%). They denied the presence of any symptoms of detrusor overactivity in their medical history, but had a diagnosis of a UTI. At least 1 month after the end of treatment and a laboratory confirmation of the absence of infection, each patient completed an OAB-Awareness Tool questionnaire (OAB signs, total score 8 points), and a noninvasive examination of urinary function (uroflowmetry). Each day patients in group A took solifenacin 10 mg and those in group B took 5 mg, with patients in group C being given a placebo.

During the study 58. 8% of patients had symptoms of an OAB at 1 month after the end of the treatment for a UTI, and normal laboratory markers. During treatment with the standard and higher dose of solifenacin, within 8 weeks most variables of the condition of the lower urinary tract reached a normal state or improved.

Patients aged >60 years who had been treated for a UTI have a high risk of developing symptoms of an OAB. Solifenacin in standard doses is an efficient and safe means of managing overactive detrusor symptoms after a UTI.

Arab journal of urology. 2015 Aug 05 [Epub]

Kirill V Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova

School of Humanities, Far Eastern Federal University, Russian Federation. , Department of Urology, City Polyclinic No. 3, Russian Federation. , Far Eastern Fisheries University, Russian Federation. , Department of the Functional Methods of Examination, Medical Association No. 2 of Vladivostok City, Vladivostok, Primorsky Region, Russian Federation.