To compare the efficacy and safety of mirabegron and vibegron in female OAB patients.
We conducted a multicenter, prospective, randomized crossover study of female patients with OAB. The patients were assigned to Group MV (mirabegron for 8 weeks, followed by vibegron for 8 weeks) or group VM (vibegron for 8 weeks, followed by mirabegron for 8 weeks). The primary endpoint was the change in OABSS from baseline, and the secondary endpoint was the change in FVC parameters. After completion of the study, each patient was asked which drug was preferable.
A total of 83 patients were enrolled (40 and 43 in groups MV and VM, respectively). At 8th and 16th week, 33 and 29 in Group MV and 34 and 27 in Group VM continued to receive the treatment. The change in PVR was not significantly different between treatment with mirabegron and vibegron. The changes in OABSS, nighttime frequency, mean, and maximum voided volume were similar between mirabegron and vibegron. The mean change in the daytime frequency was greater in the vibegron than in the mirabegron. Of the 56 patients, 15 (27%) and 30 (53%) preferred mirabegron and vibegron, respectively. The remaining 11 patients (20%) showed no preference. The change in the urgency incontinence score during vibegron was better in patients who preferred vibegron to mirabegron.
The efficacies of mirabegron and vibegron in female patients was similar. The patients' preference for vibegron could depend on the efficacy of vibegron for urgency incontinence.
World journal of urology. 2024 Mar 02*** epublish ***
Naoki Wada, Mitsuhiro Mizunaga, Noriyuki Abe, Kotona Miyauchi, Shin Kobayashi, Miyu Ohtani, Ryoken Tsunekawa, Masaya Nagabuchi, Shun Morishita, Teppei Ohyama, Satoshi Yamaguchi, Hiromichi Iuchi, Tsuyoshi Noda, Yuji Saga, Tadasu Motoya, Norihiro Kawakami, Masayuki Nishihara, Atsushi Numata, Hidehiro Kakizaki
Department of Renal and Urologic Surgery, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan. ., Nagayama Renal and Urology Clinic, Asahikawa, Japan., Department of Renal and Urologic Surgery, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510, Japan., Department of Urology, Kitasaito Hospital, Asahikawa, Japan., Department of Urology, Hokushinkai Megumino Hospital, Eniwa, Japan., Department of Urology, Fukagawa City Hospital, Fukagawa, Japan., Department of Urology, Asahikawa Rehabilitation Hospital, Asahikawa, Japan., Nishihara Nephro-Urology Clinic, Rumoi, Japan., Department of Urology, Furano Kyokai Hospital, Furano, Japan.