Obesity and Overactive Bladder: Is it a matter of body weight, fat distribution or function? A preliminary results.

To determine the relationship between subcutaneous fat (SFA), visceral fat surface area (VFA), bladder wall fat distribution, and visceral adiposity index (VAI) as risk factors for overactive bladder (OAB) occurrence.

A cross-sectional study involved 157 participants was conducted. The participants were divided into two groups; study group (87 patients diagnosed with OAB) and control group (70 healthy participants). All participants were evaluated for OAB using short-form OABSS version. Physical examination including waist circumference (WC) measurement in addition to metabolic laboratory investigations (e.g.: LDH, cholesterol, etc.) were done. Study group underwent urodynamic testing. Using NCCT, trunkal fat measurements and bladder wall fat distribution were detected. VAI was calculated for both females and males. Univariate and multivariate analyses were done to detect risk factors for OAB occurrence. Correlation between all factors and total OABSS and urodynamics was done.

The mean age ± SD was 40.4 ± 9 years. In multivariate analysis, increased VFA, higher cholesterol level, increased VAI and focal fat distribution at bladder wall were associated with 9.4, 1.98, 5.5 and 1.6 times higher risk for OAB occurrence. VAI and VFA were strongly correlated with total OABSS, DLPP, amplitude, and frequency of bladder detrusor contractions. On the other hand, WC and BMI weren't correlated significantly.

BMI and WC are crude inaccurate methods correlated with OAB presence. Focal bladder wall fat distribution, higher VAI, higher VFA are novel risk factors for OAB occurrence. Both VAI and VFA are correlated significantly to total OABSS and urodynamics findings in patients with OAB.

Urology. 2020 May 28 [Epub ahead of print]

M A Elbaset, Diaa-Eldin Taha, Doaa Elsayed Sharaf, Rawdy Ashour, Ahmed S El-Hefnawy

Urology department, Urology and Nephrology Center, Mansoura University. Electronic address: ., Urology department, KafrELshiekh University., Radiology department, Urology and Nephrology Center, Mansoura University., Urology department, Urology and Nephrology Center, Mansoura University.

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