Available α1-blockers (ABs) have different profiles of receptor selectivity. Silodosin exhibits the highest selectivity for the α1A adrenergic receptor. This pharmacological feature couples with a singular urodynamic and clinical profile. The magnitude of bladder outlet obstruction improvement in patients receiving silodosin is higher if compared to other ABs. From a clinical point of view, current evidence suggests an advantage in favor of silodosin in terms of nocturia improvement and cardiovascular safety. The incidence of ejaculatory dysfunction with silodosin is higher compared to other Abs.
Advances in therapy. 2016 Oct 17 [Epub ahead of print]
Claus G Roehrborn, Francisco Cruz, Ferdinando Fusco
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Department of Urology, Hospital de São João, Porto, Portugal. ., Department of Renal, Urologic and Infectious Disease, Faculty of Medicine, University of Porto, Porto, Portugal.