Nocturia and prevalence of erectile dysfunction in Japanese patients with type 2 diabetes mellitus: The Dogo Study.

Several epidemiological studies have reported a positive association between nocturia and erectile dysfunction (ED). Yet only limited evidence exists regarding the association between nocturia and ED among patients with type 2 diabetes mellitus, although nocturia and ED are common among type 2 diabetes mellitus patients.

Study participants were 332 male Japanese patients with type 2 diabetes mellitus, aged 19-70 years, who had undergone blood tests at our institutions. A self-administered questionnaire was used to collect information on the variables under study. Adjustment was made for age, body mass index, hypertension, stroke, ischemic heart disease, glycated hemoglobin and diabetic neuropathy. ED, moderate to severe ED and severe ED were defined as present when a participant had a Sexual Health Inventory for Men score <22, <12 and <8, respectively. Study participants were considered to have nocturia if they answered 'once or more' to the question: 'Within 1 week, how many times do you typically wake up to urinate from sleeping at night until waking in the morning?'

The prevalence of nocturia was 79.8%. Nocturia was independently positively associated with ED and moderate to severe ED: the adjusted odds ratios were 7.86 (95% confidence interval 2.11-33.56) and 2.17 (95% confidence interval 1.16-4.12), respectively. The positive association between nocturia and severe ED fell just short of significance.

In Japanese men with type 2 diabetes mellitus, nocturia might be associated with ED and moderate to severe ED.

Journal of diabetes investigation. 2016 Feb 23 [Epub ahead of print]

Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Morikazu Onji, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake

Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Japan., Department of Internal Medicine, Yawatahama General City Hospital, Yawatahama, Japan., Department of Internal Medicine, Matsuyama Shimin Hospital, Matsuyama, Japan., Department of Internal Medicine, Saiseikai Matsuyama Hospital, Matsuyama, Japan., Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan., Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan., Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan., Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Japan., Department of Internal Medicine, Ehime Prefectural Central Hospital, Matsuyama, Japan., Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Japan., Department of Internal Medicine, Saiseikai Saijo Hospital, Saijo, Japan., Department of Internal Medicine, Ehime Niihama Hospital, Niihama, Japan., Department of Internal Medicine, Saiseikai Imabari Hospital, Imabari, Japan., Department of Public Health, Juntendo University School of Medicine, Tokyo, Japan., Department of Lifestyle-related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Toon, Japan., Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan., Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Japan.