Our study investigated the association between these metabolites and male LUTS to identify metabolites using metabolomics approaches. In our study, it was revealed that pathways associated with the metabolism of amino acids could be involved in male LUTS. In fact, our data demonstrated that an increase in glutamate and decreases in arginine, asparagine, citrulline, and glutamine in plasma were associated with LUTS in males. From our data, we hypothesized the mechanism of amino acid metabolism in LUTS. Although the detailed mechanisms are unknown, changes in amino acid profiles, due to modifications in their metabolic pathways, could be caused by their enhanced metabolism in accelerated gluconeogenesis in LUTS like metabolic syndrome. Further, synthesis of nitric oxide also may be affected by changes in amino acid profiles in male LUTS.
Therefore, male LUTS may occur due to abnormal metabolisms in some pathways. Our study is the first study to show the association between amino acid profiles in plasma and LUTS. These approaches could contribute to the detection of new biomarkers. Identifying modifications in amino acid profiles may help in the development of targets for new LUTS treatment.
Written by: Takahiko Mitsui, MD, Department of Urology and Health Sciences, Graduate School of Medical Sciences, University of Yamanashi, Yamanashi, Japan
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