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The results of the study showed that the risk of SPC of any sites after a first BCa significantly increased by 60% compared with general population (SIR 1.60 95% CI 1.51-1.68). Men and younger patients presented higher risks of SPC, and overall risk of SPC was higher during the first year after BCa diagnosis than in later years. SPC were mainly found in the lungs, head, neck, and prostate sites in men with BCa, while for women, they were only localized in the lung. In the multivariate analysis, after adjusting for gender and age, the results showed a significant increase in the risk of SPC of the lung over the calendar year of BCa diagnosis. This was not observed for the head or prostate.
The high frequency of SPCs observed in the study shows the influence of aetiological and treatment related factors, specifically cigarette smoking5. The data suggests that high prevalence of smoking among patients BCa contributed to the significant increase of SPC, mainly in the lungs for both genders. The study also found that patients diagnosed with BCa have a higher risk of developing a lung that those in previous years, consistent with Freedman et al.4 In conclusion, the study suggests a correlation between smoking and higher risks of disease recurrence. These findings provide further support and evidence for the need to promote tobacco smoking cessation interventions in patients with BCa.
Authors: Joris Muller, Pascale Grosclaude, Benedicte Lapotre-Ledoux, Anne-Sophie Woronoff§, Anne-Valerie Guizard, Simona Bara, Marc Colonna, Xavier Troussard, Veronique Bouvier, Brigitte Tretarre, Michel Velten, and Jeremie Jegu
Affiliations: Bas-Rhin Cancer Registry, EA 3430, FMTS, University of Strasbourg, Department of Public Health, University Hospital of Strasbourg, Strasbourg, Tarn Cancer Registry, Albi, Francim: Reseau francais des registres des cancers, Toulouse, Somme Cancer Registry, Department of Hygiene and Public Health, University Hospital of Amiens, Amiens, Doubs and Belfort Territory Cancer Registry, University Hospital of Besancon, Besancon, Calvados General Cancer Registry, Cancers & Preventions, U 1086 Inserm, Francois Baclesse Centre, Caen, Manche Cancer Registry, Cotentin Hospital, Cherbourg-Octeville, Isere Cancer Registry, University Hospital of Grenoble, Grenoble, Basse-Normandie Haematological Malignancies Cancer Registry, University Hospital of Caen, Calvados Digestive Cancer Registry, Cancers & Preventions, U 1086 Inserm, Francois Baclesse Centre, Caen, Herault Cancer Registry, Research Center, Montpellier , and Department of Epidemiology and Biostatistics, Paul Strauss Center, Strasbourg, France
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