Elevated level of nerve growth factor in the bladder pain syndrome/interstitial cystitis: a meta-analysis

To elucidate the association between nerve growth factor (NGF) level and bladder pain syndrome/interstitial cystitis (BPS/IC) by conducting a meta-analysis.

We conducted a systematic literature search to identify original studies of NGF level in BPS/IC before November 2015. Eligible studies were retrieved via both computer searches and manual review of references. The summary difference estimates between controlled group and BPS/IC group were calculated based on the weighted mean difference (WMD) with its 95 % confidence interval (CI). Sensitivity and publication analyses were performed after the pooled analysis.

Meta-analysis of 10 original studies involving 295 cases and 290 normal controls showed an increased level of urinary NGF in BPS/IC patients (z = 3.08, P = 0.002). The combined WMD was 36.39 (95 % CI 13.27-59.51). There was significant difference between controlled group and BPS/IC patients in the term of NGF/Cr level (WMD = 0.96, 95 % CI 0.58-1.35; z = 4.89, P < 0.01). There was no significant publication bias in the included studies (P for Begg's test = 0.73, P for egger's test = 0.13).

Our results demonstrated that there was an increased level of NGF in the BPS/IC patients.

SpringerPlus. 2016 Jul 13*** epublish ***

Wei Chen, Da-Yong Ye, Deng-Jun Han, Guang-Qing Fu, Xiang Zeng, Wei Lin, Yong Liang

Department of Urology, Zigong No.4 People's Hospital, Sichuan, China., Department of Urology, Zigong No.4 People's Hospital, Sichuan, China., Department of Urology, Zigong No.4 People's Hospital, Sichuan, China., Department of Urology, Zigong No.4 People's Hospital, Sichuan, China., Department of Urology, Zigong No.4 People's Hospital, Sichuan, China., Department of Urology, Zigong No.4 People's Hospital, Sichuan, China., Department of Urology, Zigong No.4 People's Hospital, Sichuan, China.