Differences in Urodynamic Parameters between Women with Interstitial Cystitis/Bladder Pain Syndrome and Severe Overactive Bladder

OBJECTIVE - To identify differences in urodynamic parameters between female outpatients with interstitial cystitis (IC)/bladder pain syndrome (BPS) and severe overactive bladder (OAB) METHODS: This cross-sectional study included 24 and 28 consecutive IC/BPS and severe OAB female patients, respectively.

IC/BPS was defined based on the American Urological Association guideline, and severe OAB was defined based on baseline symptoms recorded in a voiding diary. Before treatment, symptom assessment using questionnaires and a 3-day voiding diary, as well as laboratory tests, were performed at the initial visit. The patients' baseline characteristics and urodynamic parameters were compared between the IC/BPS and severe OAB groups.

RESULTS - The IC/BPS group showed fewer episodes of urge incontinence and shorter duration of symptoms than the severe OAB group (P = 0.019, 0.017, respectively). Volumes at first sense, normal desire, strong desire, and maximal capacity during filling cystometry (MBC) were significantly higher in the severe OAB group than in the IC/BPS group (P < 0.001, P < 0.001, P = 0.006, P < 0.001, respectively). The IC/BPS and severe OAB groups showed significant differences in urodynamic parameters in terms of MBC and the volume discrepancy between MBC and maximal voided volume (P < 0.001, both). The ROC curve also showed an area under the curve of 0.760 and 0.783 for MBC and volume discrepancy, respectively (P < 0.001, both).

CONCLUSIONS - Data from our study suggest that combined with other clinical findings, urodynamic studies could provide useful information to differentiate between a diagnosis of IC/BPS or severe OAB.

Urology. 2016 Apr 26 [Epub ahead of print]

Ji Sung Shim, Sung Gu Kang, Jae Young Park, Jae Hyun Bae, Seok Ho Kang, Hong Seok Park, Du Geon Moon, Jun Cheon, Jeong Gu Lee, Je Jong Kim, Mi Mi Oh

Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea., Department of Urology, Korea University Medical Center, Seoul, Republic of Korea.