Influence of polyunsaturated fatty acids on urologic inflammation

Studies demonstrate that polyunsaturated fatty acids, fish oils, and alpha-linoleic acid are beneficial anti-inflammatory agents, which suppress inflammatory mediators and their activity.

This review focuses on the effects of omega-3 fatty acids (O-3FAs) on three primary urologic organs (bladder, kidney, and prostate) and associated conditions such as urolithiasis, kidney transplantation, interstitial cystitis/bladder pain syndrome, bladder cancer, prostate cancer (CaP), and chronic prostatitis/chronic pelvic pain syndrome.

The following themes emerged: the potential influence of O-3FA in suppressing urologic inflammation; the supportive role of O-3FA in therapeutic interventions; pro-inflammatory mechanisms of omega-6 fatty acids (O-6FAs) associated with disease progression; and the importance of the optimal ratio of O-6FAs/O-3FAs.

The need for further research on the role of PUFAs in suppressing urological inflammation precipitated.

International urology and nephrology. 2015 Sep 28 [Epub ahead of print]

Seetha M Tamma, Barbara Shorter, Khai-Lee Toh, Robert Moldwin, Barbara Gordon

Department of Biomedical Sciences and Chair, School of Health Professions and Nursing, Long Island University (LIU) Post, 720 Northern Blvd. , Brookville, NY, 11548, USA.  Department of Nutrition, Long Island University (LIU) Post, 720 Northern Blvd. , Brookville, NY, 11548, USA. Toh Khai Lee Urology Clinic, Mount Elizabeth Medical Centre, 3 Mount Elizabeth, Singapore, 228510, Singapore. , Pelvic Pain Center, Arthur Smith Institute for Urology, Hofstra North Shore-LIJ School of Medicine, North Shore-LIJ Health System, 450 Lakeville Road, Suite M41, New Hyde Park, NY, 11042, USA. Private Practice, Healthcomm Solutions, 2723 N Lakeharbor Lane, Boise, ID, 83703, USA. 


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