Relationship between chronic non-urological associated somatic syndromes (NUAS) and symptom severity in urological chronic pelvic pain syndromes: - Abstract

COMPLETE TITLE: Relationship between chronic non-urological associated somatic syndromes (NUAS) and symptom severity in urological chronic pelvic pain syndromes: Baseline evaluation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) study

PURPOSE: We report data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) network to: (1) identify participants having either (a) urologic chronic pelvic pain syndromes (UCPPS) only or (b) chronic functional non-urological associated somatic syndromes (NUAS) in addition to UCPPS, (2) characterize these two subgroups, and (3) explore these two subgroups using three criteria: (a) the MAPP eligibility criteria, (b) self-reported medical history, or (c) RAND interstitial cystitis epidemiologic (RICE) criteria.

MATERIALS AND METHODS: Self-reported cross-sectional data were collected from men and women with UCPPS including: predominant symptoms, symptom duration and severity, NUAS symptoms, and psychosocial factors.

RESULTS: Of 424 UCPPS participants, 162 (38%) had NUAS: 93 (22%) irritable bowel syndrome, 15 (4%) fibromyalgia, 13 (3%) chronic fatigue syndrome, and 41 (10%) with multiple syndromes. Among 233 females, 103 (44%) had NUAS compared to 59 (31%) of 191 males (p = 0.006). Participants with NUAS had more severe urological symptoms, and more frequent depression and anxiety. Of 424 participants, 228 (54%) met RICE criteria. Among 228 RICE-positive participants, 108 (47%) had NUAS compared to 54 (28%) of 203 RICE-negative patients with NUAS (p < 0.001).

CONCLUSIONS: NUAS represent important clinical characteristics of UCPPS. Participants with NUAS have more severe symptoms, longer duration and higher rates of depression and anxiety. RICE-positive patients are more likely to have NUAS and more severe symptoms. Because NUAS are more common in women, future studies need to account for this potential confounding factor in UCPPS.

Written by:
Krieger JN, Stephens AJ, Landis JR, Clemens JQ, Kreder K, Lai HH, Afari N, Rodriguez L, Schaeffer A, Mackey S, Andriole GL, Williams DA.   Are you the author?
Department of Urology, University of Washington, Seattle, WA; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Department of Urology, University of Michigan, Ann Arbor, MI; Department of Urology, University of Iowa Hospitals & Clinics, Iowa City, IA; Department of Surgery-Division of Urologic Surgery, Washington University St. Louis, St. Louis, MO; VA Center of Excellence for Stress and Mental Health & University of California San Diego, San Diego, CA; Department of Urology, University of California, Los Angeles, Los Angeles, CA; Department of Urology, Northwestern University, Chicago, IL; Department of Anesthesia-Division of Pain Management, Stanford University, Palo Alto, CA.  

Reference: J Urol. 2014 Oct 22. pii: S0022-5347(14)04767-3.
doi: 10.1016/j.juro.2014.10.086


PubMed Abstract
PMID: 25444992

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