Efficiency of O'Leary-Sant symptom index and problem index in the diagnosis of interstitial cystitis - Abstract

OBJECTIVE: To evaluate the efficiency of O'Leary-Sant problem index and symptom index (OPSI) in the diagnosis of interstitial cystitis (IC).

METHODS: A total of 82 patients, initially diagnosed as IC, with urinary frequency, urgency and pain on pubic area during bladder filling phase from January 2008 to March 2013 were enrolled.OPSI was used to evaluate their symptoms. They were eventually divided into IC and non-IC groups according to the clinical diagnosis. The scores of OPSI, interstitial cystitis problem index (ICPI) and interstitial cystitis symptom index (ICSI) were compared between two groups. And the ROC curve was plotted to screen the diagnostic specificity and sensitivity.

RESULTS: Among them, 58 were diagnosed with IC and the rest with non-IC. The average score of OPSI for groups IC and non-IC were 24.7 ± 6.9 and 23.2 ± 7.8 respectively (P = 0.403). And the ICPI score for two groups were 11.7 ± 3.2 and 10.2 ± 3.7 (P = 0.070) and the ICSI score 13.0 ± 4.0 and 13.1 ± 4.3 (P = 0.975) respectively.No significant differences existed between two groups. If an OPSI score of 12 or greater for diagnosing IC, the sensitivity was 98% and specificity 8%. Because of a high sensitivity, OPSI was a useful indicator for screening IC patients from others.In the ROC curve, acreage under curve for OPSI, ICPI, ICSI were 0.548 ± 0.071, 0.622 ± 0.069 and 0.492 ± 0.070 respectively. These three indices were not good indicators for diagnosing IC.

CONCLUSIONS: The O'Leary-Sant symptom index and problem index has a high sensitivity but a low specificity in the diagnosis of IC. Therefore it should not be used to differentiate interstitial cystitis. A cutoff OPSI value of 12 may be used for differentiation.

Written by:
Xu L1, Zhang P2, Zhang N1, Yang Y1, Wu ZJ1, Zhang CH1, Zhang XD1   Are you the author?

1Department of Urology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
2Department of Urology, Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email: .

(Article in Chinese)

Reference: Zhonghua Yi Xue Za Zhi. 2013 Nov;93(42):3347-50


PubMed Abstract
PMID: 24418029

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