Interstitial cystitis/painful bladder syndrome (IC/PBS) remains a prevalent, but untreated disease with a poorly understood pathophysiology.
Nonetheless, four main processes currently appear to be involved in producing IC/PBS symptoms: (1) disruption of the bladder GAG/proteoglycan layer, (2) upregulated immune/inflammatory response, (3) neural upregulation, and (4) pelvic floor dysfunction. Current and emerging therapies aimed at these potential targets will be the focus of this review with an update on IC/PBS therapy.
Dyer AJ, Twiss CO. Are you the author?
Department of Surgery, Section of Urology, University of Arizona Medical Center, 1501 N. Campbell Avenue, P.O. BOX 245077, Tucson, AZ, 85724-5077, USA.
Reference: Curr Urol Rep. 2014 Feb;15(2):384.