The combination therapy of prednisolone and tacrolimus for severe painful bladder syndrome/interstitial cystitis - Abstract

A 47-year-old woman visited our hospital with complaints of frequent urination and intensive pelvic pain.

Painful bladder syndrome/interstitial cystitis (PBS/IC) was suspected based on her symptoms. Hydrodistention was performed, and crack and petechial hemorrhage were found, and she was treated with tricyclic antidepressants and antihistamine. However, these treatments were ineffective. An allergy or autoimmune reaction was suspected as the pathogenesis due to eosinophilia and elevation of serum IgE levels. The patient was then treated with immunosuppressive agents. Although her symptoms were not sufficiently improved by single-agent therapy with prednisolone or tacrolimus, they were completely improved by their combined administration. This is the first case to report the effectiveness of combination therapy consisting of prednisolone and tacrolimus to treat PBS/IC.

Written by:
Kaneko G, Nishimoto K, Ito Y, Uchida A. Are you the author?
Department of Urology, Kyosai Tachikawa Hospital, Tokyo, Japan; Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Reference: Can Urol Assoc J. 2012 Apr;6(2):E46-9.
doi: 10.5489/cuaj.10134

PubMed Abstract
PMID: 22511431 Interstitial Cystitis/Painful Bladder Section