Department of Urology, Launceston General Hospital, Launceston School of Human Life Sciences, University of Tasmania, Newnham, Tasmania, Australia.
Study Type - Therapy (RCT) Level of Evidence 1b.
Objective To determine if sodium bicarbonate (Ural®) reduces painful voiding after flexible cystoscopy.
300 patients over 18 years old undergoing elective flexible cystoscopy were enrolled in a randomized, double-blinded, placebo-controlled trial. Patients with active urinary tract infections, indwelling urinary catheters and/or requiring additional procedures such as biopsy and dilatation were excluded. Painful voiding was quantified using a pain analogue scale from 0 to 10. Pre-existing painful voiding, previous experience with Ural® and flexible cystoscopy were recorded. Flexible cystoscopy was performed to a standard protocol. Patients were randomised after recruitment to receive Ural® or placebo (glucose) powder four times a day for two days after the procedure. Trial outcome was assessed by estimating the change in pain incidence and severity from before to two days after by post-procedural questionnaire.
Painful voiding was present in 84 of the 300 patients post flexible cystoscopy (45 of 160 patients receiving Ural®; 39 of 140 receiving placebo), but overall mean pain scores were low (1.25; standard deviation 2.4; on a 0-10 scale). Treatment with Ural® compared to placebo was associated with a non-significant reduction in frequency of pain (28.9% vs 31.3%; incidence rate ratio 0.66; 95% CI 0.29-1.46; P = 0.30) and severity of pain (odds ratio 0.72; 95% CI 0.30-1.74; P = 0.47).
In the replicable context of low post-cystoscopy pain levels, we believe Ural® does not reduce painful voiding after flexible cystoscopy.
Wong LM, Huang JG, Yong TL, Robertson I, Brough SJ. Are you the author?
Reference: BJU Int. 2011 Mar 25. Epub ahead of print.