The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network initiated a second observational cohort study-the Symptom Patterns Study (SPS)-to further investigate the underlying pathophysiology of Urologic Chronic Pelvic Pain Syndrome (UCPPS) and to discover factors associated with longitudinal symptom changes and responses to treatments.
This multisite cohort study of males and females with UCPPS features a run-in period of four weekly web-based symptom assessments before a baseline visit, followed by quarterly assessments up to 36 months. Controls were also recruited and assessed at baseline and 6 months. Extensive clinical data assessing urological symptoms, nonurological pain, chronic overlapping pain syndromes, and psychosocial factors were collected. Diverse biospecimens for biomarker and microbiome studies, quantitative sensory testing (QST) data under multiple stimuli, and structural and functional neuroimaging scans were obtained under a standardized protocol.
Recruitment was initiated (July 2015) and completed (February 2019) at six discovery sites. A total of 620 males and females with UCPPS and 73 Controls were enrolled, including 83 UCPPS participants who re-enrolled from the first MAPP Network cohort study (2009-2012). Baseline neuroimaging scans, QST measures, and biospecimens were obtained on 578 UCPPS participants. The longitudinal follow-up of the cohort is ongoing.
This comprehensive characterization of a large UCPPS cohort with extended follow-up greatly expands upon earlier MAPP Network studies and provides unprecedented opportunities to increase our understanding of UCPPS pathophysiology, factors associated with symptom change, clinically relevant patient phenotypes, and novel targets for future interventions.
Neurourology and urodynamics. 2020 Jun 23 [Epub ahead of print]
J Quentin Clemens, Jason J Kutch, Emeran A Mayer, Bruce D Naliboff, Larissa V Rodriguez, David J Klumpp, Anthony J Schaeffer, Karl J Kreder, Daniel J Clauw, Steven E Harte, Andrew D Schrepf, David A Williams, Gerald L Andriole, H Henry Lai, Dedra Buchwald, M Scott Lucia, Adrie van Bokhoven, Sean Mackey, Robert M Moldwin, Michel A Pontari, Alisa J Stephens-Shields, Chris Mullins, J Richard Landis
Department of Urology, Michigan Medicine, Ann Arbor, Michigan., Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California., Department of Medicine, David Geffen School of Medicine at The University of California, Los Angeles, California., Departments of Urology & Obstetrics and Gynecology, University of Southern California, Los Angeles, California., Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa., Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, Michigan., Department of Surgery, Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri., Department of Epidemiology and Medicine, Washington State University Institute for Research and Education to Advance Community Health, Seattle, Washington., Department of Pathology, University of Colorado Denver, Aurora, Colorado., Department of Anesthesiology, Perioperative, and Pain Medicine, Division of Pain Medicines, Stanford University School of Medicine, Stanford, California., Department of Urology, Hofstra University School of Medicine, The Arthur Smith Institute for Urology, New Hyde Park, New York., Department of Urology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania., Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.