Pentosan Polysulfate-Associated Macular Disease in Patients With Interstitial Cystitis.

Recent studies have implicated long-term pentosan polysulfate use with vision loss from a newly described macular condition. Affected patients report difficulty with reading and adjusting to dim lighting, and they occasionally develop severe visual disability. Macular changes resemble those seen in age-related macular degeneration, potentially leading to misdiagnosis. The objectives of this Current Commentary are to summarize studies evaluating the association between pentosan polysulfate use and macular disease, to educate pentosan polysulfate prescribers about the clinical manifestations of this condition, and to provide recommendations for screening at-risk patients.

Obstetrics and gynecology. 2020 Apr 09 [Epub ahead of print]

Riley J Lyons, Samera Ahmad, Sana Ansari, Jenelle E Foote, Nieraj Jain

Emory University School of Medicine, the Departments of Gynecology and Obstetrics and Ophthalmology, Emory University School of Medicine, and Midtown Urology, Atlanta, Georgia.