Apoptotic effect as biomarker of disease, severity and follow-up in interstitial cystitis.

To determine whether the apoptotic effect test could serve as a biomarker of severity in bladder pain syndrome/interstitial cystitis.

A prospective study was conducted between January 2010 and January 2015, which included 57 patients diagnosed with interstitial cystitis and 49 diagnosed with chronic pelvic pain of gynaecological origin. The urine was exposed to cell cultures, and the urine's capacity for inducing apoptosis in the cultures was analysed. A statistical analysis was then conducted to assess whether the apoptotic effect was associated with the symptoms.

After performing an analysis of the association between the degree of apoptotic effect and the symptoms of patients with interstitial cystitis, we observed a significant increase in the mean percentages of apoptosis as the degree of symptom severity increased. After analysing the association between the apoptotic effect and symptoms, we obtained a positive correlation in the patients with interstitial cystitis and a lack of correlation in the patients with chronic pelvic pain of gynaecological origin. The rates of apoptosis increased progressively in the patients with interstitial cystitis as the symptoms increased, while the patients with chronic pelvic pain of gynaecological origin remained stable.

The apoptotic effect of the urine of patients with interstitial cystitis could be a marker of disease, thus differentiating patients with interstitial cystitis from patients with chronic pelvic pain. The effect could also provide an objective measure of symptom severity.

Actas urologicas espanolas. 2017 Nov 10 [Epub ahead of print]

C Di Capua-Sacoto, A Sanchez-Llopis, J E Oconnor, A Martinez-Romero, J L Ruiz-Cerdá

Departamento de Urología, Hospital La Plana de Villarreal, Castellón, España., Departamento de Urología, Hospital Universitario General de Castellón, Castellón, España. Electronic address: ., Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia, España., Servicio Tecnológico de Citómica, Centro de Investigación Príncipe Felipe, Valencia, España., Departamento de Urología, Hospital Universitario La Fe, Valencia, España.