Urogenital Manifestations of Metastatic Crohn's Disease in Children: Case Series and Review of the Literature

Although cutaneous manifestations are the most common extraintestinal manifestation of inflammatory bowel disease, metastatic Crohn's disease (MCD) is rare. MCD is defined as the presence of non-caseating granulomatous inflammation and perivascular infiltrate in the cutaneous tissue that is non-contiguous to the gastrointestinal tract.

MCD rarely involves the genitourinary tract in children. When it does, it can present as external genitalia swelling, erythema, plaques or ulcerations. Here we present three pediatric cases of MCD involving the genitourinary tract. In addition to discussion of the presented cases, we have reviewed the literature on the genitourinary presentation of MCD in the pediatric population.

Urology. 2016 Feb 24 [Epub ahead of print]

Uzma Rani, Alexandra Russell, Stacy Tanaka, Hernan Correa, Maribeth Nicholson

Department of Nephrology and Hypertension, Vanderbilt University, Nashville, Tennessee., D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University, Nashville, Tennessee., Department of Pediatric Urologic Surgery, Vanderbilt University, Nashville, Tennessee., Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee., D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Vanderbilt University, Nashville, Tennessee.