Clinical analysis of management of pediatric testicular germ cell tumors - Abstract

OBJECTIVE:To analyze our experiences of pediatric testicular tumors and investigate the management of pediatric testicular germ cell tumors.

Pediatric testicular tumors are rare and the treatment of them has not been well defined.

METHODS:Children treated for primary testicular tumors between January 1998 and July 2010 were retrospectively analyzed. For yolk sac tumor, the difference of survival rates between patients with and without retroperitoneal lymph node dissection (RPLND) was calculated.

RESULTS:Eighty-seven cases met our criteria and 78 were germ cell tumors, including 40 cases with yolk sac tumor. Patients were 3-128 months old (median 19), and 53 patients were diagnosed at younger than 2 years of age. For germ cell tumors, serum α-fetoprotein and β-human chorionic gonadotropin were elevated in 48 and 7 patients, respectively, including 38 and 2 in those with yolk sac tumor. RPLND and chemotherapy were performed in 13 and 19 patients, respectively, and surveillance was performed in 50 patients. With median follow-up of 50 months, 6 patients had recurrence, 4 patients died, and the others achieved complete remission. For stage I yolk sac tumor, the difference of survival rates between patients with and without RPLND was not significant (P = .808).

CONCLUSION: Yolk sac tumor is the most common type of pediatric testicular tumor. For stage I yolk sac tumor, radical inguinal orchiectomy is effective, salvage chemotherapy is promising, and RPLND may not be necessary.

Written by:
Ye YL, Sun XZ, Zheng FF, Bian J, Huang YP, Zhang XQ, Li ZX, Nie Y, Qin ZK, Dai YP. Are you the author?
Department of Urology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Reference: Urology. 2012 Apr;79(4):892-7.
doi: 10.1016/j.urology.2011.07.1422

PubMed Abstract
PMID: 22305424

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