Cadaver donor kidney retransplantation in the pediatric patient: Complications and long-term outcome - Abstract

Departments of Urology and Pediatric Nephrology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

 

We compared the outcome of second and third kidney allografts with that of the first kidney allograft in pediatric recipients.

We classified 173 cadaveric kidney recipients into 2 groups. Group 1 comprised 120 first transplants and group 2 comprised 53 retransplants, including 43 second and 10 third transplants. We compared demographic characteristics and survival in groups 1 and 2.

Group 1 consisted of 78 boys and 42 girls with a mean ± SD age of 11.5 ± 4.2 years. Group 2 consisted of 37 boys and 16 girls with a mean age of 10.4 ± 4.7 years. One, 5, 10 and 15-year graft survival rates were 78.7%, 64.3%, 54.5% and 50.7% for first transplants vs 82.8%, 57.8%, 57.8% and 41.3%, respectively, for retransplants (p = 0.757). Patient survival at 1, 5 and 15-year was 95.8%, 89.6%, 84.9% in the first transplant group vs 93.6%, 93.6% and 93.6%, respectively, in the retransplant group (p = 0.0.63). Graft survival was significantly higher in patients who did vs did not receive calcineurin inhibitors in the 2 groups (p = 0.02).

Kidney retransplantation in the pediatric population can yield excellent long-term outcomes, especially in patients treated with calcineurin inhibitors.

Written by:
Lledó-García E, Hernández-Fernández C, Subirá-Ríos D, Díez-Cordero JM, Durán-Merino R, Herranz-Amo F, Verdú-Tartajo F, Moralejo-Gárate M, Bueno-Chomón G, Ogaya-Pinies G, Morales D, Luque-de Pablos A.   Are you the author?

Reference: J Urol. 2011 Jun;185(6 Suppl):2582-5.
doi: 10.1016/j.juro.2011.01.028

PubMed Abstract
PMID: 21527200

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