Aspects of urinary tract infections and antimicrobial resistance in hospitalized urology patients in Asia: 10-Year results of the Global Prevalence Study of Infections in Urology (GPIU)

To assess Asian data from Global Prevalence Study on Infections in Urology (GPIU study) which has been performed more than 10 years.

Seventeen Asian countries participated in the GPIU study between 2004 and 2013. Data for these countries were collected from the web-based GPIU database. The point prevalence of urinary tract infections (UTI) and antimicrobial susceptibility of representative pathogens were analysed for Asian geographic regions.

A total of 6706 patients (5271 male, 1435 female) were assessed during the study period, and 659 patients were diagnosed with a UTI (9.8%). Of these UTI patients, 436 were male and 223 were female. Mean patient age was 54.9 ± 19.3 years. Pyelonephritis and cystitis were the most common clinical diagnoses, representing 30.7% and 29.9% of patients, respectively. Escherichia coli was the most frequently identified uropathogen (38.7%). For the patients with urinary tract infection, cephalosporins were the most frequently used antibiotics (34.4%), followed by fluoroquinolones (24.1%), aminoglycosides (16.8%). Fluoroquinolone resistance was relatively high (ciprofloxacin 54.9%, levofloxacin 39.0%), and cephalosporin resistance 42% (42.5-49.4%). Of the antibiotics evaluated, uropathogens had maintained the highest level of susceptibility to amikacin and imipenem (24.9% and 11.3% resistance rates, respectively).

Uropathogens in many Asian countries had high resistance to broad-spectrum antibiotics. Knowledge of regional and local resistance data and prudent use of antibiotics are important for proper management of UTI in Asian countries.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2017 Dec 29 [Epub ahead of print]

Hyun-Sop Choe, Seung-Ju Lee, Yong-Hyun Cho, Mete Çek, Zafer Tandoğdu, Florian Wagenlehner, Truls Erik Bjerklund-Johansen, Kurt Naber, GPIU Asian Investigators

Department of Urology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, South Korea., Department of Urology, St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, South Korea. Electronic address: ., Department of Urology, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea., Department of Urology, Trakya Medical School, Edirne, Turkey., Northern Institute for Cancer Research, Newcastle University, Newcastle Upon Tyne, England, UK., Clinic of Urology, Pediatric Urology and Andrology, Justus Liebig University Giesen, Germany., Department of Urology, Oslo University, Oslo, Norway., Technical University of Munich, Dept. of Urology, Munich, Germany.


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