Diagnostic potential of trace metals concentration in expressed prostatic secretion and serum of patients with category IV prostatitis.

The National Institutes of Health (NIH) category IV prostatitis is a painless prostate gland inflammation, just as its name implies, this type of prostatitis is related with inflammation of the prostate, but most men are not conscious of it. However, category IV prostatitis is fairly common in general populations and reported having indirect relationships with prostate cancer.

We analyzed the concentration of zinc (Zn), copper (Cu), calcium (Ca) and magnesium (Mg) in expressed prostatic secretion (EPS) and serum of patients with category IV prostatitis and healthy controls, investigating the diagnostic potential of different metals in category IV prostatitis using a flame atomic absorption spectrometer (FAAS).

Metal concentration combined clinical characteristics analysis suggested that average level of Zn, Ca, Mg were significantly lower in the EPS of patients with category IV prostatitis (P-value< 0.000), while Cu level raised obviously (P-value< 0.000). And in the serum, mean concentrations of Ca was also found to increase significantly in the patients with category IV prostatitis compared to healthy controls. Moreover, the correlation analysis indicated that age showed a positive correlation with EPS Zn, Ca, Mg concentration (P-value< 0.05), while albumin correlates with EPS Zn, Ca, Mg concentration reversely (P-value< 0.05) in patients with category IV prostatitis.

Our report revealed that determination of the metal elements zinc, copper, calcium and magnesium in the serum and EPS could be a new and promising strategy for the rapid diagnosis of category IV prostatitis.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2021 Jul 08 [Epub ahead of print]

Yimin Gong, Zhidi Lin, Xiang Gan, Guoli Yang, Muyan Li, Yanjun Tan, Shengfeng Zheng, Xiao Wang, Zhongchen Luo, Yang Jiao, Ruobing Teng, Xiaoli Yang

Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China; Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China., Department of Urology, The Affiliated Hospital, Youjiang Medical University for Nationalities, Baise, Guangxi, China., Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China., Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China., Guangxi-ASEAN Collaborative Innovation Center for Major Disease Prevention and Treatment, Guangxi Medical University, Nanning, Guangxi, China., Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China., The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China., Affiliated Hospital of Guilin Medical University, Nanning, Guangxi, China., Scientific Research Center, Guilin Medical University, Guilin, Guangxi, China; Guangxi Health Commission Key Laboratory of Disease Proteomics Research, China. Electronic address: .

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