Beneficial effect of tamsulosin combined with dapoxetine in management of type III prostatitis with premature ejaculation.

To evaluate the efficacy and safety of tamsulosin combined with dapoxetine in the treatment of type IIIB chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) that is complicated by premature ejaculation (PE), a total of 251 CP/CPPS patients with PE were recruited from nine hospitals across China and were randomly divided into two groups: one received tamsulosin as a control, and the other received a combination therapy of tamsulosin and dapoxetine. Follow-up was conducted at four time points, and indicators describing CP/CPPS and PE were compared between the two groups. In all, 223 patients were followed up at least once, and 114 patients completed all of the treatment process. The combination group showed more improvement in the symptoms of both PE and CP/CPPS, including thrust number (50.5 vs. 45), premature ejaculation profile score (11.39 vs. 6.96), intravaginal ejaculation latency time (5.95 min vs. 2.63 min) and the National Institutes of Health Chronic Prostatitis Symptom Index (7.44 vs. 11.81) in comparison with the tamsulosin group. In conclusion, for CP/CPPS patients with PE, tamsulosin combined with dapoxetine provided better therapeutic efficacy in the treatment of not only PE symptoms but also CP/CPPS indicators in comparison with tamsulosin monotherapy.

Andrologia. 2019 May 27 [Epub ahead of print]

Liangyu Zhao, Ruhui Tian, Chaozhao Liang, Liyuan Zhang, Wei Song, Jun Zhao, Zengjun Wang, Zhigang Ji, Shujie Xia, Zheng Li

Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Urology Surgery Department of the First Affiliated Hospital of Anhui Medical University, Hefei, China., Andrology Department of the First Hospital of Lanzhou University, Lanzhou, China., Urology Surgery Department of Linyi People's Hospital, Linyi, China., Urology Surgery Department of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China., Urology Surgery Department of Jiangsu Province Hospital, Nanjing, China., Urology Surgery Department of Peking, Union Medical College Hospital, Beijing, China.