The role of ethanol in the pathogenesis of non‑bacterial prostatitis.

Chronic prostatitis (CP) is a common disease within the field of urology, and it is difficult to treat. Prostatitis mainly occurs in young men and presents with various clinical symptoms, manifested as urinary frequency, urinary urgency, urinary pain, prolonged urination, dysuria and other urinary abnormalities. There are various forms of the syndrome that can cause discomfort or pain in the perineum, the lower abdomen, the penis, the scrotum and the lumbosacral area. To investigate CP in more detail, animal models are necessary to determine the etiology of prostatitis and develop new, specific drug therapies. In the present study, Sprague Dawley rats that were induced to develop a model of chronic and non‑bacterial prostatitis drank ethanol or water to determine the effects of ethanol on prostatitis. Total antioxidant capacity, the concentration of inflammatory factors, such as tumor necrosis factor‑α and interleukin‑1β, and the expression changes of α1‑adrenoreceptor were measured. The susceptibility of ethanol‑drinking rats to CP was confirmed and some simple mechanism of this susceptibility was investigated to further guide the diagnosis and treatment of patients with prostatitis.

Molecular medicine reports. 2019 Feb 27 [Epub ahead of print]

Feng Liu, Lintao Liu, Zhong Wang, Lin Chen, Jianjun Yu, Xiaolin Xu

Department of Urology, Shanghai Fengxian District Central Hospital, Shanghai 201499, P.R. China.