Epidemiological studies have suggested that prostatitis may increase the risk of prostate cancer due to chronic inflammation. We studied the association between several genitourinary infections and the risk of prostate cancer based on data from the EPICAP study. EPICAP is a population-based case-control study conducted in the département of Hérault, France, between 2012 and 2014. A total of 819 incident cases and 879 controls have been face to face interviewed using a standardized questionnaire gathering information on known or suspected risk factors of prostate cancer, and personal history of genitourinary infections: prostatitis, urethritis, orchi-epididymitis, and acute pyelonephritis. Odds Ratios (OR) and their 95% confidence interval were estimated using multivariate unconditional logistic regression. Overall, 139 (18%) cases and 98 (12%) controls reported having at least one personal history of genitourinary infections (OR=1.64 [1.23-2.20]). The risk increased with the number of infections (p-trend<0.05). The association was specifically observed with personal history of chronic prostatitis and acute pyelonephritis (OR=2.95 [1.26-6.92] and OR=2.66 [1.29-5.51], respectively) and in men who did not use any Non-Steroidal Anti-Inflammatory Drugs (OR=2.00 [1.37-2.91]). Our results reinforce the hypothesis that chronic inflammation, generated by a personal history of genitourinary infections, may play a role in prostate carcinogenesis. This article is protected by copyright. All rights reserved.
International journal of cancer. 2018 Apr 26 [Epub ahead of print]
Solène Doat, Miguelle Marous, Xavier Rebillard, Brigitte Trétarre, Pierre-Jean Lamy, Paolo Soares, Olivier Delbos, Rodolphe Thuret, Bruno Segui, Sylvie Cénée, Florence Menegaux
Université Paris-Saclay, Université Paris-Sud, CESP (Center for Research in Epidemiology and Population Health), Inserm, Team Cancer and Environment, Villejuif, France., Service Urologie, Clinique Beau Soleil, Montpellier, France., Registre des Tumeurs de l'Hérault, Montpellier, France., Polyclinique Saint Privat, Béziers, France., Cabinet Urologie du Polygone, Montpellier, France., Centre Hospitalo-Universitaire, Hôpital Lapeyronie, Montpellier, France.