New treatment modalities have been developed to improve the treatment outcomes of Peyronie's disease (PD). Stem cells are undifferentiated cell populations that are capable of self-renewal and of differentiation into various kinds of cells or new tissues. In addition, stem cells also have antiapoptotic, antifibrotic, and immunomodulatory properties. The results from preclinical studies support the potential role of adipose-derived stem cells (ADSCs) therapy for both the prevention and treatment of PD. However, there are several limitations of the animal model used in the studies. Further animal and clinical studies are still needed to validate the therapeutic effects and clinical application of ADSCs for the treatment of PD.
Translational andrology and urology. 2016 Jun [Epub]
Division of Urology, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.