Use of A Non Cross-Linked Xenograft (Xenform®) in Surgical Treatment of Peyronie's Disease.

To evaluate the effectiveness in Peyronie's Disease surgical treatment using Xenform®, a non cross-linked graft derived from dermal bovine tissue, to close the defect obtained after plaque incision, without penile prosthesis implant. A further objective is to evaluate the satisfaction of patients.

We treated with plaque incision 28 patients with a stable penile curvature ≥ 60° hindering penetration and with erectile function conserved. IIEF-15 and a not-validate questionnaire constituted of seven questions about their satisfaction were administered after 1 year of follow-up. Furthermore, specific questions were relative about penile straightening, penile postoperative length, glandular sensitivity and feeling palpability.

Graft is resulted compatible with albugineal features, like thickness, consistency and elasticity; it is waterproof allowing the visualization of complete correction of the curvature after the suture. No severe complications were observed except one hematoma requiring surgical revision. 16 patients were seen after at least 1 year of follow-up. Curvature improvement was obtained in all cases, with the complete straightening in 75%; we didn't observe any retraction of the graft and any recurrence on the curvature. Significant reduced glans sensibility and erectile dysfunction were the more frequent postoperative complications, resulting in 43,8% and 25% respectively. All patients are satisfied for the straightening. And only 2 patients are unsatisfied about the overall result.

Plaque incision corporoplasty with Xenform® graft is an effective and safe surgical treatment. Xenform® is a secure and a reliable albugineal substitute, comparable to the others heterologous graft. We haven't observed any retraction. Patient's satisfaction is linked to the treatment result and to sexual life.

Urology. 2016 May 31 [Epub ahead of print]

Enrico Caraceni, Luca Leone, Lilia Utizi, Angelo Marronaro

Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Via dei Ginevri, Civitanova Marche 62012, Italy.. Electronic address: ., Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Via dei Ginevri, Civitanova Marche 62012, Italy.. Electronic address: ., Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Via dei Ginevri, Civitanova Marche 62012, Italy.. Electronic address: ., Urology Operative Unit, Civitanova Marche Hospital, Area Vasta 3 Asur Marche, Via dei Ginevri, Civitanova Marche 62012, Italy.. Electronic address: .

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