Peyronie's disease arises from the deposition of collagen and fibrin which creates a plaque in the tunica albuginea of the penis.
The resulting induration and curvature of the penis leads to sexual dysfunction in many men. Despite the prevalence of the disease and natural history studies that suggest progression, men may not seek therapeutic intervention due to a lack of general knowledge about the disease, its pathophysiology, and treatments aimed at ameliorating its symptoms. Medical therapy using oral, topical, or intralesionally delivered drug is pursued in all but the most severe cases. This review of the literature in the last four years attempts to identify new trials of therapies and treatment modalities aimed at altering the Peyronie's disease process. Specifically, we will address clinical trials evaluating oral pharmacotherapies, topical, intralesional, and shockwave therapies, and penile traction devices. We will discuss the level of evidence and support for each of the new clinical trials.
Schaeffer AJ, Burnett AL. Are you the author?
Reference: J Androl. 2011 Feb 24. Epub ahead of print.