Only a few studies have investigated the association between the severity of Peyronie's disease (PD) and clinical parameters such as age and associated comorbidities.
The aim of this study was to report the relationship between the degree of the curvature of the penis and the clinical parameters among patients with PD. A total of 1001 patients with PD were evaluated retrospectively in terms of penile deformity, erectile status and risk factors for systemic vascular diseases. The degree of curvature was assessed with a protractor during maximum erection in response to a combined injection and stimulation (CIS) test and/or vacuum device. A modified Kelami classification was used to categorize penile deformities as follows: patients with deformities without a curvature (notching, hourglass and swan neck deformity, Group 1), with mild (≤ 30°, Group 2), moderate (31-60°, Group 3) or severe curvatures (>60°, Group 4). Chi-square tests, one way ANOVA and univariate and multiple ordinal regression analyses were used for statistical analysis. Penile deformity without curvature was detected in 12.3% of the patients, whereas the curvature was < 30° in 39.5%, 30-60° in 34.5% and >60° in 13.5% of the patients. Multiple ordinal regression analysis identified age (p = 0.013), side of deformity (p = 0.007), erectile dysfunction (p < 0.0001) and diabetes mellitus (DM) (p = 0.001) as significant independent predictors of the severity of the penile curvature. In conclusion, patients' age, side of deformity, erectile function and DM were significantly associated with the degree of curvature.
Kadioglu A, Sanli O, Akman T, Canguven O, Aydin M, Akbulut F, Kucukdurmaz F. Are you the author?
Reference: J Androl. 2011 Jan 13. Epub ahead of print.