Conservative treatment of Peyronie's disease: a guide.

To review the literature on the topic, to suggest a common line of treatment applicable across a wide community of specialists, and to contribute in maintaining the high level of interest in this disease.

A comprehensive and exhaustive review of the literature was performed, identifying hundreds of articles on the topic.

Peyronie's disease is a condition that has been recognized, studied, and treated for centuries; despite this, if one excludes surgery in cases in which the deformity is stable, no clear treatment (or line of treatment) is available for complete relief of signs and symptoms. Treatment options were divided into local, oral, and injection therapy, and a wide variety of drugs, remedies, and options were identified.

Low-intensity extracorporeal shock wave therapy, vacuum therapy, penile traction therapy, phosphodiesterase type 5 inhibitors, hyaluronic acid, and collagenase of Clostridium histolyticum may be recommended only in specific contexts. Further studies on individual options or potential combinations are required.

World journal of urology. 2024 May 13*** epublish ***

Marco Cosentino, Michele Di Nauta, Luca Boeri, Giordana Ferraioli, Gianpaolo Lucignani, Anna Ricapito, Franco Gadda, Massimo Iafrate, Mariangela Mancini, Fabrizio Dal Moro, Eduard Ruiz-Casta├▒e, Carlo Bettocchi, Emanuele Montanari, Nikolaos Sofikitis

Uro-Andrology Department, Casa di Cura Villa Maria, Via delle Melette 22, 35138, Padua, Italy. ., Department of Urology and Organ Transplantation, Università di Foggia, Foggia, Italy., Department of Urology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy., Urology Clinic, Department of Surgical, Oncological and Gastroenterological Sciences, Padova University, Padua, Italy., Andrology Department, Fundacio Puigvert, Universitat Autonoma de Barcelona, Barcelona, Spain., Department of Urology, Ioannina University School of Medicine, Ioannina, Greece.