Use of grafting materials during penile prosthesis implantation in patients with Peyronie's disease-a systematic review.

Severe Peyronie's disease (PD) and concomitant erectile dysfunction (ED) may require plaque incision/excision and grafting (PIG) as an adjunct to penile prosthesis implantation (IPP). Currently, there is no available consensus on the best graft material to use. Our aim was to systematically review graft materials used as patches following PIG + IPP. Literature search was performed in March 2021. Only original articles in English with a series of 10 or more patients were included. Overall, a total of 17 studies were included, corresponding to a cohort of 662 patients. The mean age ranged from 45 to 65 years and most patients had curvatures >45°. Average penile lengthening ranged from 1 to 3.5 cm, average residual curvatures from 0 to 20% and decreased glans sensitivity from 0 to 20%. Eighty to 100% of patients were satisfied with cosmetic and functional results. PIG + IPP with the use of various grafts offers promising results for the treatment of patients suffering from severe PD with concomitant ED. Unfortunately, the absence of high quality and comparative studies makes it difficult to establish the optimum graft. Therefore, the level of experience of the surgical team with one or more methods should guide their choice.

International journal of impotence research. 2021 Oct 30 [Epub ahead of print]

Francesco Chierigo, Carlo Bettocchi, Felix Campos-Juanatey, Fabio Castiglione, Luis A Kluth, Carlo Terrone, Asif Muneer, Trauma and Reconstructive Urology Working Party of the European Association of Urology Young Academic Urologists (YAU) , ESSM Scientific Collaboration and Partnership (ESCAP)

Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, Italy., Department of Medical and Surgical Sciences of University of Foggia, Foggia, Italy., Department of Urology, Marqués de Valdecilla University Hospital, Santander, Spain., Department of Urology, University College London Hospital, London, UK. ., Department of Urology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany., Department of Urology, University College London Hospital, London, UK.

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