We aimed to evaluate the effectiveness and safety of penile plaque incision and buccal mucosa grafting in patients with stable-phase Peyronie's disease (PD).
This was a prospective evaluation of patients with stable-phase PD who were treated by plaque incision and buccal mucosa grafting. Preoperative evaluation included International Index of Erectile Function Questionnaire (IIEF-5), measurement of erect penile length, and penile Doppler ultrasound during prostaglandin-induced erection. At 3- and 24-month follow-up visits, penile length and residual curvature were measured along with penile Doppler ultrasound and IIEF5 questionnaires. Patient and sexual partner satisfaction were also assessed at 24-month-visit.
The study was completed with 20 patients (mean age 46.5 ± 9.9 years). Dorsal curvature was the most frequent site of curvature (45%). The median curvature at preoperative evaluation was 45°(range 40-90°). The postoperative median curvatures were 5°(5-10, IQR) and 7°(5-10, IQR) at 3- and 24-month postoperatively, respectively. Success rate was 95% at 3-month and 90% at 24-month. There was no significant penile shortening. The mean IIEF-5 score was 17.5 ± 2.2 at preoperative evaluation. The median IIEF-5 scores were calculated as 20.1 ± 2.2 and 21.3 ± 2.2 at 3-month and 24-month visits, respectively (p<0.0001). Compared with baseline IIEF-5 score, both postoperative IIEF-5 scores were significantly higher. There was no de novo erectile dysfunction. There were no serious complications during and after the surgery. Ten percent of patients were poorly satisfied with the results of the surgery.
Corporoplasty with buccal mucosa graft led to excellent structural and functional results and patient satisfaction. Ainayev Y, Zhanbyrbekuly U, Gaipov A, et al. Surgical Reconstruction of Penile Curvature due to Peyronie's Disease by Plaque Incision and Buccal Mucosa Graft. J Sex Med 2021;XXX:XXX-XXX.
The journal of sexual medicine. 2021 Jun 17 [Epub ahead of print]
Yernur Ainayev, Ulanbek Zhanbyrbekuly, Abduzhappar Gaipov, Makhmud Suleiman, Kainar Kadyrzhanuly, Nurlan Kissamedenov, Ulan Zhaparov, Daniyar Akhmetov, Gafur Khairli
Department of Urology and Andrology, Astana Medical University, Beybitshilik Street 49a., 010000, Nur-Sultan, Kazakhstan. Electronic address: ., Department of Urology and Andrology, Astana Medical University, Beybitshilik Street 49a., 010000, Nur-Sultan, Kazakhstan., Departmen of Medicine, Nazarbayev University School of Medicine, Kerey and Zhanibek Khans Street 5/1, 010000, Nur-Sultan, Kazakhstan., Department of Reception and Diagnosis, JSC 'National Center of Neurosurgery', Turan Street 34/1, 010000, Nur-Sultan, Kazakhstan.