Sperm cryopreservation before treatment for testicular and other cancers and its subsequent utilization for the treatment of infertility, "Beyond the Abstract," by Jana Žáková

BERKELEY, CA (UroToday.com) - The Assisted Reproduction Centre in the Faculty Hospital Brno is the oldest and largest workplace in the Czech Republic where cancer patients’ sperm is cryopreserved. Thanks to a strong awareness among urology specialists and availability of sperm cryopreservation, the number of patients referred for this procedure has quickly increased. Between October 1995 and the end of December 2012 we cryopreserved semen of 1 111 men with cancer.

Malignant testicular tumor (a total of 523 patients, 47.4 %) was the most common diagnosis in patients who were referred for sperm cryopreservation, followed by patients with Hodgkins lymphoma (199 patients, 17.8 %), leukemia (119 patients, 10.6 %), or non-Hodgkins lymphoma (72 patients 6.5 %). Sixty-eight men were treated for malignant tumors of bone and cartilage (6.1 %). Other malignant diseases occurred only sporadically. In young adolescent boys (13 – 16 years) the most frequent diagnosis was malignant tumor of bone and cartilage (25.0 %), followed by leukemia (16.7 %), Hodgkins lymphoma (13.9 %), and testicular tumor (11.1 %).

Frozen/thawed semen samples can be used in the future for infertility treatment by assisted reproduction techniques (intrauterine insemination, oocyte fertilization by classical in vitro fertilization, or by intracytoplasmic sperm injection).

Sperm preparation is simple. Semen is left at room temperature and allowed to recuperate for 20 minutes. Thawed semen samples are then washed twice with washing medium to eliminate seminal plasma. Motile spermatozoa are collected by a “swim-up” procedure. The final suspension is kept at 37° C for 2 hours before insemination.

Sperm cryopreservation should be offered to every patient before therapy that causes the destruction of spermatogenesis.

Written by:
Jana Žáková as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic

Sperm cryopreservation before testicular cancer treatment and its subsequent utilization for the treatment of infertility - Abstract

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