Where are we going with gene screening for male infertility?

Male infertility is a heterogenous disease process requiring the proper functioning and interaction of thousands of genes. Given the number of genes involved, it is thought that genetic causes contribute to most cases of infertility. Identifying these causes, however, is challenging. Infertility is associated with negative health outcomes, such as cancer, highlighting the need to further understand the genetic underpinnings of this condition. This paper describes the genetic and genomic tests currently available to identify the etiology of male infertility and then will discuss emerging technologies that may facilitate diagnosis and treatment of in the future.

Fertility and sterility. 2019 May [Epub]

Nannan Thirumavalavan, J Scott Gabrielsen, Dolores J Lamb

Scott Department of Urology, Baylor College of Medicine, Houston, Texas., Department of Urology, Center for Reproductive Genomics and Caryle and Israel Englander, Institute for Precision Medicine, Weill Cornell School of Medicine, New York, New York. Electronic address: .