Metabolic syndrome (MetS) represents a cluster of conditions that have a negative impact on human health overall. Its prevalence has been rapidly increasing worldwide and has coincided with a global decrease in birth rates and fertility potential. This review aims to address this observation through studying the relationship between MetS and male reproductive health. The effects of obesity, dyslipidemia, hypertension, and insulin resistance on male fertility were examined and supporting evidence explaining the pathophysiology of sperm dysfunction with each MetS component were described. Adopting a healthy lifestyle appears to be the single most important intervention to prevent the unwanted effects of MetS on men's health and fertility. Further studies addressing the components of MetS and their impact on male reproduction are required to enhance our understanding of the underlying pathophysiology and to propose new methods for therapeutic intervention.
The world journal of men's health. 2018 Oct 22 [Epub ahead of print]
Ana Dias Martins, Ahmad Majzoub, Ashok Agawal
American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA., Department of Urology, Hamad Medical Corporation and Weill Cornell Medicine-Qatar, Doha, Qatar., American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA. .