OBJECTIVE: To evaluate the efficacy of daily low-dose tadalafil in the treatment of erectile dysfunction (ED) following pelvic fracture-induced urethral injury (PFUI).
METHODS: Based on the length of time between pelvic fracture and the patients' clinic visit, we divided 42 PFUI-caused ED patients into groups A (< 1 month), B (6-24 months) and C (> 24 months). We treated them with tadalafil at 5 mg daily for 12 weeks consecutively, followed by evaluation of the therapeutic effect using IIEF-5 questionnaire and Sexual Encounter Profile (SEP) diaries.
RESULTS: Thirty-four patients (83.3%) completed the investigation and all responded well to tadalafil medication. Group A showed significant differences from B and C in the increase of IIEF-5 scores and the positive rate of SEP.
CONCLUSION: Daily low-dose tadalafil helps penile rehabilitation in ED patients following PFUI, and the earlier the medication is initiated, the better the effect will be.
Written by:
Tang YX, Gan Y, Zhang XB, Zhu XS, Jiang XZ, He LY, Yang JF. Are you the author?
Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Reference: Zhonghua Nan Ke Xue. 2013 Jun;19(6):539-41.
PubMed Abstract
PMID: 23862234
Article in Chinese.
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