Erectile dysfunction (ED) is associated with metabolic disorders like hypertension and diabetes. The lipid accumulation product (LAP), a marker of visceral fat and dyslipidemia, has not been well studied in relation to ED in these populations. This study examined the relationship between LAP and ED.
A cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) 2001-2004 data included 756 men with hypertension or diabetes. Weighted multivariable logistic regression and restricted cubic spline (RCS) analysis evaluated LAP-ED associations, with subgroup analysis for effect modification.
ED prevalence was 43.65% (330/756). LAP correlated positively with ED risk (continuous: OR = 1.005, 95%CI:1.000-1.005). Highest vs lowest LAP quartile (Q4 vs Q1) showed 2.92-fold higher ED risk (OR = 2.92, 95%CI:1.21-7.06). RCS analysis indicated linear association (P for non-linearity = 0.290). Subgroup analysis showed no significant interactions.
This study demonstrates a positive correlation between LAP and ED in men with diabetes or hypertension; further studies are needed to confirm findings and explore mechanisms.
The aging male : the official journal of the International Society for the Study of the Aging Male. 2025 Sep 18 [Epub]
Maobin Yu, Ze Li, Hongsen Zeng, Jian Ma, Hang Deng, Meijun Liu, Tao Zhang, Zilong Xu, Peihai Zhang
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China., Department of Andrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.