Fixed-dose combination therapy with dutasteride and tamsulosin in the management of benign prostatic hyperplasia

Despite their multifactorial etiology, male lower urinary tract symptoms (LUTS) have been traditionally associated with benign prostatic enlargement (BPE) because of benign prostatic hyperplasia (BPH).

Several pharmaceutical therapies have been used to manage LUTS, with α1-adrenergic receptor antagonists (α1-blockers) and inhibitors of 5α-reductase (5α-RIs) representing the most commonly prescribed agents currently in use for LUTS treatment. Due to their different modes of action, combined use of α1-blockers and 5α-RIs has been proven to offer more optimal control of symptoms and better associated quality of life, even though higher rates of adverse events have been shown. Following previous studies on the separate administration of dutasteride and tamsulosin, a fixed-dose combination capsule of tamsulosin 0. 4 mg and dutasteride 0. 5 mg has been approved and released for clinical use in men with BPH. The present review aims to discuss the rationale behind the combined use of tamsulosin and dutasteride for treating male LUTS, and to present the available data on the role of combination therapy in the management of BPH-related symptoms in terms of efficacy and safety. Special attention is given to the impact of combination treatment on the prevention of clinical progression of BPH. Cost-effectiveness of fixed-dose combination and patients' adherence to treatment are also discussed.

Therapeutic advances in urology. 2016 Feb [Epub]

Konstantinos Dimitropoulos, Stavros Gravas

Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece. , Department of Urology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Feidiou 6-8, Larissa 41221, Greece.

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