Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years. Older diabetics tend to have both impaired insulin release as well as insulin resistance. There is growing evidence indicating the pathophysiological connections among the mechanisms of oxidative damage by disruption of the oxidative balance, increased levels of enzymatic glycation products in testicular region and glucose transporters, obesity and proinflammatory cytokines in male infertile patients with diabetes. Epidemiological studies suggest that many clinical findings in diabetics are linked to low testosterone levels. This article reviews pathophysiological mechanisms, observational studies, and clinical implications of testosterone therapy in type 2 diabetes mellitus.
Current pharmaceutical design. 2017 Aug 22 [Epub ahead of print]
Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T Scotti, Rajeev K Singla, Thonos Alexiou, Atanas G Atanasov, Vadim V Tarasov, P Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Pharmacology Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, Andhra Pradesh. India., Center of Nutrition, Council for Agricultural Research and Economics (CREA-NUT), Via Ardeatina 546, 00178 Rome. Italy., Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam-530 045, Andhra Pradesh. India., Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169. United States., School of Life Sciences, Shanghai University, Shanghai 200444. China., Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C.. Colombia., King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589. Saudi Arabia., Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, 58051-900 João Pessoa, PB. Brazil., Division of Biological Sciences & Engineering (Formerly Biotech Division), Netaji Subhas Institute of Technology, University of Delhi, Dwarka, New Delhi-xxx x78. India., Novel Global Community Educational Foundation. Australia., Molecular Biology Department, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec. Poland., Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya st., 119991 Moscow. Russian Federation., Department of Biotechnology, Krishna University, Machilipatnam-521 001, A.P.. India., Department of Obstetrics & Gynecology, Andhra Medical College, Visakhapatnami. India., Department of Biochemistry, University of Allahabad, Allahabad, 211 002Uttar Pradesh. India., Department of Medical, Oral and Biotechnological Sciences, University "G. D'Annunzio", Via dei Vestini 31, 66100 Chieti. Italy., Department of Experimental Medicine, Università della Campania, Via Costantinopoli, 16, 80138 Naples. Italy., Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka, 142432. Russian Federation.