Bisphosphonate related osteonecrosis of the jaws (BRONJ) in osteoporotic males

The purpose of this study was to describe the clinical characteristics of bisphosphonate related osteonecrosis of the jaws (BRONJ) in osteoporotic males.

The medical records of BRONJ patients from 2007 to 2014 were reviewed. The data from only the male patients was extracted, and demographic data was collected and biochemical markers were measured.

11 Patients out of 210 (5 %) being males. Among the 11 patients, the indication of bisphosphonate (BP) was osteoporosis in 9 patients, and cancer in two. In one of the osteoporosis patients, osteoporosis was thought to be secondary to hypogonadism after testicular tumor resection. Serum c-terminal telopetide crosslink of type I collagen (s-CTX) values ranged from 60 to 165 pg/mL (mean: 84.6 ± 36.8, median: 70). Serum osteocalcin (s-OC) ranged from 0 to 5.06 ng/mL (mean: 1.83 ± 1.66, median: 1.5) and vitamin D ranged from 0 to 11.9 (mean: 5.02 ± 4.92, median: 3.5).

BRONJ can be overlooked in male patients with osteoporosis. Although the incidence of BRONJ in males may be low, dentists should also check if their male patients are on osteoporosis treatment since osteoporosis in males can be manifested as a secondary disease to hypogonadism.

SpringerPlus. 2016 Sep 01*** epublish ***

Yong-Dae Kwon, Chae-Yoon Lee, Sung Ok Hong, Yeon-Ah Lee, Joo-Young Ohe, Deog-Yoon Kim

Department of Oral and Maxillofacial Surgery, Graduate School, Kyung Hee University, Seoul, Republic of Korea., Division of Rheumatology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea., Department of Nuclear Medicine, Kyung Hee University School of Medicine, Seoul, 02447 Republic of Korea.