This study examined the effect of Testofen, a specialised Trigonella foenum-graecum seed extract on the symptoms of possible androgen deficiency, sexual function and serum androgen concentrations in healthy aging males.
This was a double-blind, randomised, placebo-controlled trial involving 120 healthy men aged between 43 and 70 years of age. The active treatment was standardised Trigonella foenum-graecum seed extract at a dose of 600 mg/day for 12 weeks. The primary outcome measure was the change in the Aging Male Symptom questionnaire (AMS), a measure of possible androgen deficiency symptoms; secondary outcome measures were sexual function and serum testosterone. There was a significant decrease in AMS score over time and between the active and placebo groups. Sexual function improved, including number of morning erections and frequency of sexual activity. Both total serum testosterone and free testosterone increased compared to placebo after 12 weeks of active treatment. Trigonella foenum-graecum seed extract is a safe and effective treatment for reducing symptoms of possible androgen deficiency, improves sexual function and increases serum testosterone in healthy middle-aged and older men.
The aging male : the official journal of the International Society for the Study of the Aging Male. 2016 Jan 20 [Epub ahead of print]
Amanda Rao, Elizabeth Steels, Warrick J Inder, Suzanne Abraham, Luis Vitetta
a Department of Medicine , University of Sydney , Sydney , Australia . , b Integrated Health Group, Clinical Research , Brisbane , Australia . , c Department of Diabetes and Endocrinology , Princess Alexandra Hospital , Brisbane , Australia , and. , a Department of Medicine , University of Sydney , Sydney , Australia . , a Department of Medicine , University of Sydney , Sydney , Australia .