Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function - Abstract

Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms.

Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.

Written by:
Golan R, Scovell JM, Ramasamy R.   Are you the author?
Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA.

Reference: Aging Male. 2015 Jun 15:1-4.
doi: 10.3109/13685538.2015.1052392


PubMed Abstract
PMID: 26075536

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