The emancipation of testosterone from niche hormone to multi‑system player - Full Text Article

It is no exaggeration to say that our conceptualization of the (patho‑) physiological functions of testosterone has undergone a revolutionary development over the last three decades. The traditional thinking was that the biological functions of testosterone were restricted mainly to the area of reproduction and male sexuality. However, scientific research has clearly demonstrated that testosterone is a multi‑system hormone serving a wide range of hitherto unsuspected biological functions.

aju logoIn line with this, it will be argued in this contribution that the physiological role of testosterone has been underestimated, while the risks of testosterone administration have been overstated. Space does not permit to elaborate extensively on all new insights of the role of testosterone in the biology of the male. Three areas will be addressed: (1) the role that testosterone can play in body weight management of hypogonadal men; (2) the role of testosterone in inflammatory processes; (3) the strategy required to let patients benefit from the recent insights that testosterone is a multi‑system hormone whose use should not be limited to reproductive/sexual medicine.

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Written by:
Farid Saad1, 2   Are you the author?
1Bayer Pharma, Global Medical Affairs Andrology, Berlin, Germany.
2Gulf Medical University School of Medicine, Ajman, United Arab Emirates.

Reference: Asian J Androl. 2014 Sep 9.
doi: 10.4103/1008-682X.137684

PubMed Abstract
PMID: 25248654