Hypogonadism in the HIV-infected man - Abstract

Androgen deficiency occurs frequently in men with human immunodeficiency virus (HIV) infection.

Antiretroviral treatments had reduced the prevalence of male hypogonadism. The pathogenesis of testosterone (T) deficiency in HIV is multifactorial. Several mechanisms have been proposed; among them, drugs, fat redistribution, and a poor health status could explain the mechanism leading to gonadotropins inhibition and hypogonadotropic hypogonadism. The diagnosis of hypogonadism in HIV-infected men should be made based on clinical symptoms and a specific workup including T measurement. The interpretation of the results of biochemical testing is more difficult in men with HIV due to several confounding factors. T treatment should be offered to HIV-infected men with documented clinical hypogonadism and symptoms, especially if they are losing lean mass.

Written by:
Rochira V, Guaraldi G.   Are you the author?
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Azienda USL of Modena, Modena, Italy; Infectious and Tropical Disease Unit, Department of Medical and Surgical Sciences of Mother, Child and Adult, Metabolic Clinic, University of Modena and Reggio Emilia, Via del Pozzo 71, Modena 41124, Italy.  

Reference: Endocrinol Metab Clin North Am. 2014 Sep;43(3):709-730.
doi: 10.1016/j.ecl.2014.06.005

PubMed Abstract
PMID: 25169563

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