Clinical Trials

27 results for Bladder Cancer


Molecular Correlates of Sensitivity and Resistance to Therapy in Genitourinary Malignancy

  • Condition: Healthy Control, Localized Urothelial Carcinoma of the Renal Pelvis and Ureter, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Soft Tissues, Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter, Recurrent Bl
  • Intervention: Other: Cytology Specimen Collection Procedure, Other: Laboratory Biomarker Analysis
  • Study ID: NCT01050504
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A Phase 1 Study of Cabozantinib Plus Nivolumab (CaboNivo) Alone or in Combination With Ipilimumab (CaboNivoIpi) in Patients With Advanced/Metastatic Urothelial Carcinoma and Other Genitourinary Tumors

  • Condition: Malignant Reproductive System Neoplasm, Malignant Urinary System Neoplasm, Metastatic Urethral Neoplasm, Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter, Progressive Neoplastic Disease, Recurrent Bladder Carcinoma, Recurrent Urethra C
  • Intervention: Drug: Cabozantinib S-malate, Biological: Ipilimumab, Other: Laboratory Biomarker Analysis, Biological: Nivolumab
  • Study ID: NCT02496208
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A Phase I, Open-label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK3326595 in Subjects With Solid Tumors and Non-Hodgkin's Lymphoma

  • Condition: Cancer
  • Intervention: Drug: GSK3326595 Capsules
  • Study ID: NCT02783300
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Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer of the Bladder and Kidney

  • Condition: Urothelial Cancer, Cancer, Bladder Neoplasms, Urinary Bladder Cancer
  • Study ID: NCT00872495
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Atezolizumab in Combination With Gemcitabine and Cisplatin As First-Line Treatment in Metastatic Urothelial Cancer: A Multicenter Randomized Phase II Study of Two Alternative Dosing Schedules

  • Condition: Urothelial Carcinoma, Locally Advanced, Unresectable
  • Intervention: Drug: Atezolizumab, Drug: Gemcitabine, Drug: Cisplatin
  • Study ID: NCT03093922
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A Phase 1b, Open-label, Multicenter Study to Investigate the Safety and Preliminary Efficacy of NKTR 214 and Anti-PD-L1 (Atezolizumab) in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer or Metastatic Non-Small Cell Lung Cancer

  • Condition: Non-Small Cell Lung Cancer, Urinary Bladder Neoplasms, Neoplasm Metastasis
  • Intervention: Drug: Combination of NKTR-214 + atezolizumab
  • Study ID: NCT03138889
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Intervention of Advanced or Metastatic Urothelial Bladder Cancer by 4SCAR-T Cell Therapies

  • Condition: Bladder Cancer, Urothelial Carcinoma Bladder
  • Intervention: Genetic: 4SCAR-PSMA, Genetic: 4SCAR-FRa
  • Study ID: NCT03185468
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Four Cycles of Cisplatin-Based Chemotherapy in Metastatic Urothelial Carcinoma Compared to Six Cycles: Randomized Phase III Trial - FOCUS Study -

  • Condition: Bladder Cancer, Ureter Cancer, Urethral Cancer, Transitional Cell Carcinoma
  • Intervention: Drug: Treatment duration of cisplatin based chemotherapy
  • Study ID: NCT03296306
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Phase 2 Trial of Olaparib in Patients With Metastatic Urothelial Cancer Harboring DNA Damage Response Gene Alterations

  • Condition: Metastatic Urothelial Cancer
  • Intervention: Drug: Olaparib
  • Study ID: NCT03448718
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A Phase II Study of Dose-Dense Gemcitabine Plus Cisplatin (ddGC) in Patients With Muscle-Invasive Bladder Cancer With Bladder Preservation for Those Patients Whose Tumors Harbor Deleterious DNA Damage Response (DDR) Gene Alterations

  • Condition: Infiltrating Bladder Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma, Stage III Bladder Urothelial Carcinoma
  • Intervention: Drug: Gemcitabine Hydrochloride, Drug: Cisplatin, Biological: Pegfilgrastim, Procedure: Conventional Surgery, Procedure: Radical Cystectomy, Other: Chemoradiotherapy
  • Study ID: NCT03609216
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A Phase 2 Study of Sitravatinib in Combination With Nivolumab in Patients With Advanced or Metastatic Urothelial Carcinoma

  • Condition: Urothelial Carcinoma, Urothelial Carcinoma Bladder, Urothelial Carcinoma Ureter, Urothelial Carcinoma of the Renal Pelvis and Ureter, Urothelial Carcinoma Urethra
  • Intervention: Drug: Sitravatinib, Drug: Nivolumab
  • Study ID: NCT03606174
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Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers

  • Condition: Non-metastatic Muscle Invasive Bladder Cancer
  • Intervention: Drug: Avelumab, Procedure: cystectomy, Combination Product: CG, Combination Product: DD-MVAC, Combination Product: PG
  • Study ID: NCT03674424
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Cabozantinib Plus Pembrolizumab as First-Line Therapy for Cisplatin-Ineligible Advanced Urothelial Carcinoma (PemCab)

  • Condition: Metastatic Urothelial Carcinoma, Bladder Cancer
  • Intervention: Drug: Cabozantinib, Drug: Pembrolizumab
  • Study ID: NCT03534804
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Gemcitabine-cisplatin Plus Avelumab or Gemcitabine-cisplatin as First-line Treatment of Patients With Locally Advanced or Metastatic Urothelial Bladder Carcinoma (GCISAVE)

  • Condition: Bladder Carcinoma
  • Intervention: Drug: Avelumab, Drug: GC
  • Study ID: NCT03324282
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DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

  • Condition: Acinar Cell Carcinoma, Adrenal Cortex Carcinoma, Adrenal Gland Pheochromocytoma, Anal Canal Neuroendocrine Carcinoma, Anal Canal Undifferentiated Carcinoma, Appendix Mucinous Adenocarcinoma, Bladder Adenocarcinoma, Bronchioloalveolar Carcinoma, Ce
  • Intervention: Procedure: Biospecimen Collection, Biological: Ipilimumab, Biological: Nivolumab
  • Study ID: NCT02834013
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A Prospective, Single Arm, Multicenter, Phase II-Trial to Assess Safety and Efficacy of Preoperative RAdiation Therapy Before Radical CystEctomy Combined With ImmunoTherapy in Locally Advanced Urothelial Carcinoma of the Bladder

  • Condition: Urinary Bladder Cancer
  • Intervention: Drug: Nivolumab, Radiation: Radiation therapy of the pelvis, Procedure: Radical cystectomy with standardized pelvic lymphadenectomy
  • Study ID: NCT03529890
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A Randomized Phase II Trial of Atezolizumab With or Without Bevacizumab in Cisplatin-ineligible Patients With Advanced/Unresectable Urothelial Cancer: Hoosier Cancer Research Network GU15-215

  • Condition: Urothelial Carcinoma
  • Intervention: Drug: Atezolizumab, Drug: Bevacizumab
  • Study ID: NCT03272217
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A Phase 3, Randomized, Double-blind Study to Compare the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Lenvatinib (E7080/MK-7902) Versus Pembrolizumab and Placebo as First Line Treatment for Locally Advanced or Metastatic Urothelial C

  • Condition: Urothelial Carcinoma
  • Intervention: Biological: Pembrolizumab, Drug: Lenvatinib, Drug: Placebo for lenvatinib
  • Study ID: NCT03898180
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Phase II Trial of Neutron Radiotherapy With Concurrent Checkpoint Inhibitor Immunotherapy (Pembrolizumab) in Patients With Advanced Urothelial Carcinoma

  • Condition: Urothelial Carcinoma
  • Intervention: Other: Laboratory Biomarker Analysis, Biological: Pembrolizumab, Radiation: Radiation Therapy
  • Study ID: NCT03486197
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A Pilot Study of Tazemetostat and MK-3475 (Pembrolizumab) in Advanced Urothelial Carcinoma

  • Condition: Advanced Urothelial Carcinoma, Locally Advanced Urothelial Carcinoma, Metastatic Bladder Urothelial Carcinoma, Metastatic Urothelial Carcinoma, PD-L1 Positive, Stage III Bladder Cancer AJCC v8, Stage IIIA Bladder Cancer AJCC v8, Stage IIIB Bladder
  • Intervention: Biological: Pembrolizumab, Drug: Tazemetostat
  • Study ID: NCT03854474
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A Phase II Trial to Evaluate Combination Therapy With Pemetrexed and Avelumab in Previously Treated Patients With MTAP-Deficient Advanced Urothelial Cancer

  • Condition: Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant, Infiltrating Bladder Urothelial Carcinoma With Glandular Differentiation, Infiltrating Bladder Urothelial Carcinoma With Squamous Differentiation, Infiltrating Bladder Urothelial Carcinoma,
  • Intervention: Drug: Avelumab, Drug: Pemetrexed
  • Study ID: NCT03744793
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Neoadjuvant Chemotherapy Versus Surgery Alone in Patients With High-Grade Upper Tract Urothelial Carcinoma

  • Condition: High-Grade Upper Tract Urothelial Carcinoma
  • Intervention: Procedure: Radical nephroureterectomy, Procedure: Distal ureterectomy, Drug: Neoadjuvant Chemotherapy
  • Study ID: NCT02876861
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A Window-of-opportunity Trial of Abemaciclib Followed by Radical Cystectomy in Patients With Platinum-ineligible Urothelial Carcinoma to Evaluate CDK4/6-dependent Phosphorylation of Pocket Proteins and Clonal Evolution Dynamics

  • Condition: Bladder Cancer
  • Intervention: Drug: Abemaciclib
  • Study ID: NCT03837821
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Phase II Study of Avelumab in Combination With AXL Inhibitor AVB-S6-500 in Patients With Advanced Urothelial Carcinoma

  • Condition: Urothelial Carcinoma
  • Intervention: Drug: Avelumab, Drug: AVB-S6-500
  • Study ID: NCT04004442
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An Open-label, Randomized, Controlled Phase 3 Study of Enfortumab Vedotin in Combination With Pembrolizumab With or Without Chemotherapy, Versus Chemotherapy Alone in Previously Untreated Locally Advanced or Metastatic Urothelial Cancer

  • Condition: Urothelial Cancer
  • Intervention: Drug: Enfortumab vedotin, Drug: Pembrolizumab, Drug: Cisplatin, Drug: Carboplatin, Drug: Gemcitabine
  • Study ID: NCT04223856
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A Randomized Open-Label Phase III Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Subjects With Metastatic or Locally Advanced Unresectable Urothelial Cancer (TROPiCS-04)

  • Condition: Urothelial Carcinoma, Bladder Cancer, Metastatic Urothelial Carcinoma, Locally Advanced Urothelial Cancer, Transitional Cell Carcinoma
  • Study ID: NCT04527991
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A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated, Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

  • Condition: Uterine Neoplasms, Uterine Cervical Neoplasms, Biliary Tract Neoplasms, Urologic Neoplasms, Carcinoma, Non-Small-Cell Lung, Breast Neoplasms
  • Study ID: NCT04579380
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